Associate Director, Pharmacometrics

Categories: Clinical Pharmacology
Crinetics is a pharmaceutical company based in San Diego, California that develops much-needed therapies for people with rare endocrine diseases. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and robust pipeline across preclinical and clinical development. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Come join our team as we transform the lives of others.
Position Summary:
Crinetics Pharmaceuticals is seeking an experienced pharmacometrician to join its growing and dynamic team. This individual will use quantitative clinical pharmacology approaches to answer important clinical questions and support model-informed drug development decisions. Multiple programs, interesting challenges, and strong cross-functional collaborators will allow the successful candidate to make a substantial impact and enhance their career development.
Essential Functions and Responsibilities:
These may include but are not limited to:
  • Work within program teams to understand and anticipate the quantitative needs of each project
  • Contribute to efficient clinical study designs with respect to PK and PD
  • Assist in formulation of program- and study-level analysis plans
  • Hands-on use of modeling and simulation tools to understand complex PK, PK/PD, and exposure-response data
  • Interpret analysis results generating actionable conclusions and new hypotheses
  • Collaborate with partner CROs to accomplish goals across multiple programs
  • Communicate model-informed interpretations and advice to project teams
  • Prepare applicable sections of regulatory documents
Education and Experience:
  • Pharm.D./ Ph.D. with 8 years minimum work experience, or B.S./M.S. degree in Pharmacokinetics, Pharmacometrics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a strong understanding of pharmacology principles with minimum of 10 years’ work experience. An equivalent combination of experience and education may be considered
  • Industry experience is a plus
  • Familiarity with all stages of clinical drug development
  • Demonstrated ability to design experiments/studies and prepare analysis plans and reports
  • Experience in the endocrinology and/or pediatric spaces
  • Expertise with relevant software
  • Ability to communicate effectively in written and graphical formats to influence decisions
  • Ability to collaborate across departments and with external partners
  • Must have sufficient experience to work independently
Physical Demands and Work Environment:
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.
You may be required to travel for up to 5% of your time. 
The Anticipated Base Salary Range: $161,000 – $184,000
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws
Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.