Principal Scientist Metabolic Diseases

Categories: Biology
The Principal Scientist, Metabolic Diseases, will be responsible for identifying and co-leading projects in obesity, diabetes, and related metabolic diseases. The candidate will also leverage in vivo and ex vivo pharmacology expertise including designing, conducting, and interpreting experiments to demonstrate both the efficacy and safety of novel nonpeptide drug candidates in animal and primary culture models.  Strategic, leadership and laboratory responsibilities are all important aspects of this role.
These may include but are not limited to:
  • Serve as a co-Program Lead to guide, coordinate, and implement cross-functional activities for Discovery programs for metabolic disease programs
  • Lead external collaborations and outsourced studies
  • Lead and supervise junior scientists
  • Present findings at team/cross-functional and corporate meetings in addition to scientific conferences
  • Drive the identification, evaluation of new targets; contribute to prioritization assessment
  • Design, conduct, and interpret in vivo experiments to evaluate the efficacy, pharmacokinetics, and safety of development candidate molecules in support of drug discovery programs
  • Demonstrate a high level of initiative to troubleshoot and accurately perform data analysis on in vivo studies
  • Design or conduct ex vivo assays in metabolically relevant cell-types
  • Analyze and present experimental data using Prism, Excel, MS Office or comparable software
  • Responsible for ensuring compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards
  • Perform timely data verification and ensure accuracy for laboratory notebooks, protocols, reports, and regulatory filings
Other duties as assigned
  • Ph.D. in Biology, Metabolic Disease, Neuroscience, Behavioral Pharmacology, Physiology, Endocrinology, or related discipline with a minimum of 12+ years of relevant experience
  • 5+ years of experience in drug development in the area of metabolic diseases
  • Strong knowledge of central mechanisms in energy balance and glucose homeostasis
  • Experience in program management/leadership is desired
  • Experience in designing and conducting obesity and diabetes in vivo models
  • Experience in designing and conducting ex vivo studies in primary cultures of relevance to metabolic disease is desired
  • Experience with non-GLP rodent toxicity studies is a plus
  • Hands on proficiency in rodent handling procedures and in vivo skills including dosing (IV, PO, SC), blood and tissue collection, necropsy, etc. is preferred
  • Proficiency with basic surgical techniques is preferred
  • Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature
  • Able to effectively communicate and present summaries of research results
  • Must have a strong work ethic and be enthusiastic for animal and laboratory work
  • Must be detail-oriented, punctual, reliable, and available on weekends when necessary
  • Strong written and verbal communication skills and ability to work effectively in a multidisciplinary team environment
  • Ability to work in a fast-paced environment and adapt to change
Equipment:   PC, scanners, voice mail and e-mail systems, and common office machines, or ability to be trained.  Knowledge of other equipment required: N/A
Software Knowledge:  Windows, MS Office (Outlook, Word, Excel), Prism or equivalent statistical and graphing software.
Physical Activities:  Intermittent standing and walking over long periods of time may be required.  Sitting for long periods of time working at a desk may be required.  Lifting up to 20 lbs. may be required.  The noise level in the work environment is usually low to moderate.  The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities, if applicable:  Biology, chemical laboratory and vivarium environment experience needed. Environmental health and safety requirements also apply.
Travel may be required up to 5% of your time.
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown in December.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.
Crinetics Pharmaceuticals Inc. ( is a rare endocrine and endocrine-related cancer therapeutics company. Crinetics’ benefit package includes health insurance, stock options, a 401k, paid time off, and the company provides a dog-friendly work environment.