Senior Director, Health Economics and Outcomes Research

Categories: HEOR
Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.
 
Position Summary:
The Senior Director, Health Economics and Outcomes Research (HEOR) will be responsible for developing evidence to support Paltusotine within the Acromegaly program throughout its lifecycle management. The Senior Director will design, implement, and manage HEOR studies, focusing on patient reported outcomes (PROs), registries, and observational and retrospective studies. The Senior Director is a highly visible role and will closely collaborate with cross-functional partners including Regulatory, Clinical Research, Clinical Operations, Biometrics, Medical Affairs, Patient Advocacy, and Commercial to successfully incorporate HEOR strategies and RWE to support the development and commercialization of Paltusotine.
 
Essential Job Functions and Responsibilities:
These may include but are not limited to:
  • Lead, plan, and execute the pre-, peri, and post-launch HEOR research program for Paltusotine in collaboration with cross-functional teams, external KOLs, consultants, and vendors
  • Focus on immediate and short-term (<2 Years) strategic planning horizon
  • Provide leadership, career management, coaching and mentoring to others on the team and cross-functionally
  • Recruit and develop top talent. Align team to needs of the business
  • Drive team objectives and goal setting, prioritization, and adherence to plan and strategy
  • Lead and manage a de novo disease and patient registry for Acromegaly patients, including developing and updating research protocols, interpret of findings, and externally communicate and publish results to the wider scientific, medical, and patient communities
  • Lead the development of the PRO dossier to support NDA filing for Paltusotine
  • Contribute to the design, PRO endpoint selection, and reporting and analysis of clinical studies
  • Develop economic evaluations including cost-effectiveness models to support value propositions
  • Document unmet needs by demonstrating economic and humanistic burden in planned/approved indications for Paltusotine
  • Develop publications and external communications based on HEOR and RWE studies
  • Collaborate with cross-functional partners to develop value dossiers (i.e. AMCP, GVD, HTA)
  • Conduct patient and caregiver surveys as appropriate to support value propositions
  • Collaborate with disease and HEOR KOLs to develop position papers of interest
  • Identify critical future HEOR capability gaps, develop and lead the strategy for capability development, skills and standards to ensure consistently high performance
  • Attend medical/scientific, pharmacy, and HEOR professional meetings to keep up with changing trends and remain current within the field relating to new research and medical trends affecting acromegaly
  • Other duties as assigned
 
Education and Experience:
Required:
  • Advanced degree related to health economics and/or health outcomes research (MSc, MPH, PhD, PharmD)
  • Minimum of 13 years of relevant pharmaceutical/ consulting HEOR experience, and a minimum of 10 years of supervisory experience
  • Preferred breadth of experience to include PRO development, economic models, dossier development, registries, RWE studies including claims analyses, chart reviews, and other observational prospective and retrospective studies to be considered at the Sr. Director level
  • Ability to impact, influence, and interact with senior business leaders and partners
  • Experience and awareness of Global and Regional Reimbursement and Access environments
  • Demonstrable success in employing innovative techniques to overcome data limitations
  • Excellent analytical skills, including in-depth technical expertise and experience, knowledge of health economic modeling, patient-reported outcome measures and outcomes research methodologies
  • Experience of exceptional collaboration with other functions (e.g., biometrics, clinical research, medical affairs, patient advocacy and commercial)
  • Possesses excellent communication and interpersonal skills especially over departmental and geographical boundaries
  • Ability to lead, collaborate and influence cross-functional teams
  • Ensure compliance with corporate policies and procedures, as well as US healthcare laws and regulations
  • Flexible, adaptable, diplomatic, and able to effectively deal with ambiguity
  • Possesses a good blend of strategic and operational experience with the ability to see the big picture and strong attention to detail
 
Physical Demands and Work Environment:
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
 
Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.
 
Travel:
You may be required to travel for up to 5% of your time.
 
The Anticipated Base Salary Range: $230,000 – $287,000
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.
 
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.
 
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
 
Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.