Vice President, Health Economics and Outcomes Research
Categories: Medical Affairs
POSITION SUMMARY:
The Vice President, Health Economics and Outcomes Research (HEOR) will provide the vision and strategic leadership required to support the value proposition of Crinetics pipeline assets from product development through lifecycle management. As a key member of the Medical Sciences leadership team, the VP, HEOR is responsible for developing and implementing strategic pre-and post-marketing patient experience research and for managing the planning, implementation and publishing of HEOR focusing on clinical trial patient reported outcomes, disease registries, observational and retrospective epidemiologic studies in disease areas of interest to Crinetics and through the product life cycle. The Vice President is responsible for cultivating and maintaining relationships with HEOR experts, globally and partner with experts to communicate the value proposition of Crinetics’ therapies. The Vice President, HEOR will be accountable for providing insights to Early Development, Clinical, R&D, Commercial/Marketing/Market Access, Medical Affairs regarding the incorporation of HEOR and RWE to support development and commercialization of Crinetics products.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES:
These may include but are not limited to:
- Develop and implement HEOR research strategy and plans, initially focused on Paltusotine value and access for Acromegaly and Carcinoid Syndrome, as well as broader R&D pipeline
- Work closely with commercial and market access teams to lead the development of Health Economic strategy and plans to optimize market access for Paltusotine and pipeline programs
- Orchestrate fulfillment of strategic research plan in collaboration with cross-functional teams, including Commercial, R&D, and Medical Affairs
- Leverage existing registries and EHR databases to support regulatory requirements, address payer evidence generation and help reimbursement activities
- Research and perform critical analyses of medical and scientific evidence including systematic reviews, RWE, and economic evaluations as the basis for HTA assessments, disease management guidelines, and formulary evaluations
- Leading and creating GVD & AMCP dossiers
- Lead, plan and execute pre-, peri-, and post-launch HEOR research program, with external vendors, and consultants or internal staff as appropriate
- Engage external KOLs to provide insights to Crinetics registries and observational research
- Provide input into registry data analytics and methodologies
- Document unmet needs by demonstrating economic and humanistic burden of illness in planned/approved indications for products
- Contribute to the design, HEOR endpoint selection, reporting and analysis of clinical studies including subgroup analyses
- Demonstrate product value versus comparator through mixed treatment comparison or indirect treatment comparison methods as appropriate
- Develop cost-effectiveness model-based economic evaluations, budget impact analyses, cost-offset analyses and burden of illness studies
- Support scientific content output (abstracts/manuscripts/posters) based on HEOR & RWE analyses for products
- Conduct patient and caregiver surveys to support value propositions
- Implement innovative approaches to the design of rare disease registries (if applicable)
- Strategically interact with external organizations to help shape and manage the disease reviews and leverage internal cross functional team (commercial, market access, regulatory, clinical development, patient advocacy, medical affairs, corporate communications) to shape the continuous dialogue with external stakeholders
- Partner with HEOR KOLs and disease KOLs to develop position papers on topics of interest to Crinetics
- Identify academic collaborations to ensure credibility and trust in analyses, as well as gain access to novel data sources
- Identify, select, establish, and manage a global network of vendors and consultants as needed to implement and deliver on HEOR strategy
- Build collaborative relationships with cross-functional leaders across R&D, Commercial, Market Access and Pricing to optimize launches and demonstrating value throughout the product lifecycle
- Identify critical future HEOR capability gaps, develop and lead the strategy for capability development, skills and standards to ensure consistently high performance
- Foster innovation, and create and manage innovative approaches to evidence synthesis, tools, and resources
- Responsible for providing training to internal stakeholders (payer account managers, payer MSLs, Medical Affairs, Market Access) and external partners on cost-effectiveness models, budget impact models, disease reviews, and HEOR abstracts and papers
- Attend medical/scientific, pharmacy, and HEOR professional meetings to keep up with changing trends and remain current within the field relating to new research and medical trends affecting each product area
- Build and lead a sophisticated, scientific, and efficient HEOR team, to support the successful launch, and ongoing lifecycle management of Crinetics’ products
- Player/coach with team leadership skills and the ability to manage, mentor, and develop team is required
- Provide direct support to senior leadership in all HEOR matters as may be required
- Develop policies, procedures and process flows to provide efficient and effective operations
- Ensure compliance with corporate policies and procedures, as well as US healthcare laws and regulations
- Develop and manage departmental budgets and hiring plans that effectively achieve desired goals that are balanced with the financial objectives of the broader medical organization
EDUCATION AND EXPERIENCE
- Advanced degree related to health economics and/or health outcomes research (MSc, MPH, PhD, PharmD).
- 15 years of relevant pharmaceutical/ life science HEOR experience
- 14 years of experience in a management/leadership role
- Preferred breadth of experience to include endocrinology
- Ability to impact, influence, and interact with senior business leaders and partners.
- Experience and awareness of Global and Regional Reimbursement and Access environments
- Experience of Health Technology Appraisals (HTA) processes
- Demonstrable success in employing innovative techniques to overcome data limitations
- Excellent analytical skills, including in-depth technical expertise and experience, knowledge of health economic modeling, patient-reported outcome measures and outcomes research methodologies
- Experience of exceptional collaboration with other functions (e.g., market access, pricing, medical affairs, patient advocacy and commercial)
- Possesses excellent communication and interpersonal skills especially over departmental and geographical boundaries
- First line people management experience including demonstrable expertise in team effectiveness and development
- Budget management
- Extremely effective interpersonal skills with an ability to influence management and network across functions and be a participative and effective member of a leadership team
- Strong leadership, interpersonal, entrepreneurial, management, presentation, and writing skills required; self-motivated & proactive
- Track record in building leading, motivating, and training successful team members in an entrepreneurial clinical lab
- Ability to lead, collaborate and influence cross-functional teams
- Flexible, adaptable, diplomatic, and able to effectively deal with ambiguity
- Possesses a good blend of strategic and operational experience with the ability to see the big picture and strong attention to detail
TECHNICAL KNOWLEDGE REQUIRED:
Equipment: PC, scanners, voice mail and e-mail systems, and common office machines, or ability to be trained.
Software Knowledge: Windows, MS Office (Outlook, Word, Excel, PowerPoint). Knowledge of other software preferred: Veeva (MSL, CRM).
PHYSICAL DEMANDS AND WORK ENVIRONMENT
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
TRAVEL:
Travel may be required up to 20% of your time, and ability to travel globally as needed.
THE ANTICIPATED BASE SALARY RANGE: $350,000 – $384,000
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown in December.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws
Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.
ABOUT CRINETICS:
Crinetics Pharmaceuticals Inc. (www.crinetics.com) is a rare endocrine disease and endocrine-related cancer therapeutics company. Crinetics’ benefits package includes health insurance, stock options, ESPP, a 401k, paid time off, and the company provides a dog-friendly work environment.