About Acromegaly
Acromegaly is a hormonal disorder resulting from the excess secretion of growth hormone, most commonly due to a benign pituitary tumor. Excessive growth hormone (GH) secretion in turn causes excessive secretion of another hormone, insulin-like growth factor I(IGF-I). Symptoms from the pituitary tumor itself can include severe headaches, vision impairment, and impaired pituitary endocrine function. Excess GH and IGF-I secretion can also cause increased bone and soft tissue growth including changes in facial shape, enlarged hands and feet, and a range of cardiovascular, respiratory, endocrine, and metabolic morbidities. If not adequately treated, acromegaly can lead to serious illness and become life-threatening. The prevalence of acromegaly has been estimated at approximately 9 cases per 100,000 persons with a total estimated U.S. patient population of 28,000.About CRN00808
CRN00808 is an orally available nonpeptide biased agonist of the somatostatin sst2 receptor that has demonstrated robust efficacy in animal models of excess growth hormone secretion. It is the product of Crinetics’ internal drug discovery efforts that are focused on identifying novel drug candidates for a range of rare endocrine diseases and endocrine-related cancers. CRN00808 is the lead program in Crinetics’ growing pipeline of drug candidates.About the NIDDK
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) conducts and supports research on diabetes and other endocrine and metabolic diseases; digestive diseases, nutrition, and obesity; and kidney, urologic, and hematologic diseases. Spanning the full spectrum of medicine and afflicting people of all ages and ethnic groups, these diseases encompass some of the most common, severe, and disabling conditions affecting Americans. For more information about the NIDDK and its programs, visit www.niddk.nih.gov.About Crinetics Pharmaceuticals
Crinetics Pharmaceuticals discovers and develops novel therapeutics targeting peptide hormone receptors for the treatment of rare endocrine disorders and endocrine-related cancers. Crinetics was founded by a team of scientists with a proven track record of endocrine drug discovery and development to create important new therapeutic options for endocrinologists and their patients. The company is backed by top life sciences investors, 5AM Ventures, Versant Ventures, and Vivo Capital and is headquartered in San Diego.
Investors:
Gayathri Diwakar
Head of Investor Relations
[email protected]
(858) 345-6340
Media:
Natalie Badillo
Head of Corporate Communications
[email protected]
(858) 450-6464
