Senior Scientist 2, Metabolic Diseases

Categories: Metabolic Diseases
Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.
Position Summary: The Senior Scientist 2, Metabolic Diseases will be responsible for conducting mechanistic and differentiation studies critical to programs in obesity, diabetes, and related metabolic diseases. The candidate will also contribute significantly to new target identification and provide scientific contributions across metabolic disease programs.
Job Location: Onsite in San Diego, CA
Essential Job Functions and Responsibilities:
These may include but are not limited to:
  • Drive the identification and evaluation of new targets in diabetes, obesity or related metabolic diseases.
  • Design, develop and conduct ex vivo assays in metabolically relevant cell-types.
  • Lead in vitro initiatives in metabolic disease drug development programs.
  • Lead external collaborations and outsourced studies.
  • Contribute to the proposal and evaluation of biomarkers to inform on PK/PD relationships and mechanism of action.
  • Present findings at team/cross-functional meetings and scientific conferences.
  • Demonstrate a high level of initiative to troubleshoot and accurately perform data analysis on in vivo studies.
  • Analyze and present experimental data using Prism, Excel, MS Office or comparable software.
  • Ensure compliance with company established practices and procedures, including laboratory notebooks, computer files, quality and regulatory guidelines, and safety standards.
  • Perform timely data verification and ensure accuracy for laboratory notebooks, protocols, reports, and regulatory filings.
Education and Experience:
  • Ph.D. in Biology, Metabolic Disease, Neuroscience, Behavioral Pharmacology, Physiology, Endocrinology, or related discipline with a minimum of 8+ years of relevant experience.
  • 3 years of experience in drug discovery in metabolic diseases.
  • Experience in leading components of metabolic disease drug discovery programs is desired; demonstrated potential to eventually assume a program leadership role is essential.
  • Experience in designing and conducting ex vivo studies in primary cultures of relevance to metabolic disease, minimally including experience in hepatocyte and adipocyte models.
  • Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature.
  • Able to effectively communicate and present summaries of research results
  • Must have a strong work ethic and be enthusiastic for animal and laboratory work.
  • Must be detail-oriented, punctual, reliable, and available on weekends when necessary.
  • Strong written and verbal communication skills and ability to work effectively in a multidisciplinary team environment.
  • Ability to work in a fast-paced environment and adapt to change.
Equipment:   PC, scanners, voice mail and e-mail systems, and common office machines, or ability to be trained.  Knowledge of other equipment required: N/A
Software Knowledge:  Windows, MS Office (Outlook, Word, Excel), Prism or equivalent statistical and graphing software.
Physical Demands and Work Environment: Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.
You may be required to travel for up to 5% of your time.
The Anticipated Base Salary Range:  $141,000-$188,000
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.