Senior Director, Commercial Supply Chain
Categories: CMC (MFG)
Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully-integrated endocrine company from discovery to patients. Join our team as we transform the lives of others.
Position Summary:
The Senior Director of Commercial Supply Chain will provide leadership and management in the planning, optimization, expansion, and execution of commercial supply chain activities to ensure the efficient and effective production and delivery of our innovative biotechnology products. The individual will demonstrate leadership ability and end-to-end commercial supply chain expertise, be able to work independently and enjoy working in a dynamic, complex, fast-paced environment during a period of significant growth and global expansion. They will be a hands-on leader with a deep understanding of all aspects of supply chain management, from production to distribution. They will also be a strong communicator and collaborator with a demonstrated ability to build and motivate high-performing teams.
Essential Job Functions and Responsibilities:
These may include but are not limited to:
These may include but are not limited to:
- Manage the global integrated S&OP process to align Crinetics’ priorities and strategies with operational plans and achieve improved financial and patient impacts.
- Focus on immediate and short-term (<2 Years) strategic planning horizon.
- Provide leadership, career management, coaching and mentoring to others on the team and cross-functionally.
- Drive team objectives and goal setting, prioritization, and adherence to plan and strategy.
- Provide management oversight for drug product serialization for all Crinetics’ products globally; partner with serialization companies such as Tracelink and the supply chain market leads (responsible for Europe, North America, Rest of World, Distributor Markets, Alliance Partners) to ensure serialization/onboarding readiness for global launches.
- Develop operating model through vendors and internal compliance team to ensure adherence to global trade compliance regulations.
- Direct leadership of manufacturing operations for drug substance, drug product, supply chain, and distribution.
- Lead supply chain planning – ensure all elements of drug substance allocation, drug product management, jurisdictional control restrictions at the finished goods level, lot traceability, etc. are appropriately allocated to ensure supply reliability including effective decision making.
- Manage and oversee end-to-end supply chain Standard Operating Procedures (SOPS) and champion process improvements and transformation initiatives where applicable to streamline and remove redundancy.
- Develop and implement business continuity models to mitigate the end-to-end supply chain for Crinetics’ commercial products.
- Manage supply chain finances/budget by leading budgetary review/updates, reviewing and approving invoices, and adapting supply chain practices for financial adherence.
- Oversight and leadership of CMO partner operations and stakeholder management.
- Lead negotiation efforts for major contracts and global distribution agreements.
- Evolve the 3PL global footprint for worldwide distribution, driving economies of scale where applicable.
- Keep abreast of any changes in regulatory requirements that may impact our end-to-end planning and distribution of Crinetics’ products globally.
- Lead supply chain teams during audits.
- Partner with Clinical, Commercial, CMC, Quality, and Regulatory to ensure that operations are aligned with the company’s overall strategy and meet operational requirements.
- Other duties as assigned.
Education and Experience:
Required:
- Bachelor’s degree in science, engineering, supply chain or another related technical field. Advanced degree preferred.
- 15+ years of progressive technical operations management experience in biotechnology or pharmaceutical industry, and a minimum of 10 years in a supervisory role.
- Deep understanding of all manufacturing and supply chain management aspects, from product development to distribution.
- Demonstrated experience with managing operating budgets.
- Successful experience in working with Procurement, CMOs and 3PLs.
- Proven understanding of global pharmaceutical distribution requirements.
- Proven experience of global pharmaceutical regulatory / registration requirements.
- Demonstrated strong understanding and track record of cGMP, GMP manufacturing, FDA guidelines, regulatory inspections, supply chain operations and quality standards.
- Excellent communication, problem-solving, and decision-making skills.
- Demonstrated cross-functional partnerships with all key internal stakeholders such as Quality, Regulatory, IT, HR, Legal, Finance, and other departments.
Preferred:
- Experience in global trade compliance would be beneficial.
- Experience with cold chain would be beneficial.
Physical Demands and Work Environment:
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.
Travel:
You may be required to travel for up to 35% of your time.
You may be required to travel for up to 35% of your time.
The Anticipated Base Salary Range: $217,000 – $260,000
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.
The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.