Director, DMPK

Categories: DMPK
Crinetics is a pharmaceutical company based in San Diego, California that develops much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were Crinetics is a pharmaceutical company based in San Diego, California that develops much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and robust pipeline across preclinical and clinical development. We are driven by science with a patient-centric and team-oriented culture. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Come join our team as we transform the lives of others.

Position Summary:
The Director, DMPK will report to the Vice President of DMPK and will primarily liaise with our highly dynamic Chemistry, Pharmacology, and Toxicology departments to develop strategies and advance discovery programs to the clinic. The individual will also collaborate with clinical pharmacology and CMC members at Crinetics and provide scientific leadership and guidance in resolving drug metabolism and clinical drug-drug interactions issues that evolve during clinical development of advanced drug candidates. The individual should have strong scientific training in all areas of DMPK and a demonstrated track record of leading focused DMPK groups in the biotechnology or pharmaceutical industry. This role is located at our San Diego headquarters.

Essential Job Functions and Responsibilities:
These may include but are not limited to:

  • Serve as the DMPK lead in multifunctional discovery and early development program teams.
  • Serve as a Program Lead to guide, coordinate, and implement cross-functional activities for Discovery programs.
  • Manage effective cross-functional collaboration, especially with in vitro/in vivo pharmacology and toxicology and provide guidance in the optimization of drug leads and candidates, in understanding of PK/PD and human dose projections.
  • Provide scientific leadership and guidance to DMPK team members as a direct supervisor and educate colleagues across different functions.
  • Contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion.
  • Develop and implement DMPK strategies to support discovery and development programs using internal resources and CROs.
  • Recommend, initiate, lead, and implement innovative technologies and approaches to enhance scientific impact and/or efficiencies and ensure that cutting edge science is applied to project related issues.
  • Oversee and be responsible all aspects of nonclinical and clinical drug metabolism and DDI in support of development programs.
  • Recommend timing for DM (Human ADME studies) and DDI studies needed to support clinical trials and NDA submissions.
  • Create and foster strong partnerships with all groups at Crinetics. Be a subject matter expert and educate all disciplines with regards to applications of DMPK principles to drug development.
  • Oversee completion of relevant DMPK reports and documents for development candidate nomination and regulatory filings including reports, Investigator Brochures, and INDs (or equivalent).
  • Contribute to cross-functional review of all regulatory documents and author and review DMPK sections for relevant regulatory documents e.g. reports, IND, IB, MAA.
  • Ability to identify the need for clinical drug-interaction studies based on fundamental understanding of metabolic and transporter-based drug interactions.
  • Serve as a subject matter expert and help in composing regulatory queries related to DMPK issues.
  • Work with the discovery senior management to recruit scientists and build a team to support the DMPK strategy and drive the discovery engine. 
  • Set clear outcomes/deliverables for projects and own them, staying accountable to the company management team.
  • Other duties as assigned.
Education and Experience:
Required:
  • PhD in relevant discipline with 15+ years of relevant experience. Applicants with BS or MS degrees may apply but must demonstrate a minimum of 20+ years of significant and relevant experience.
  • Minimum supervisory experience of 8 plus years.
  • Excellent verbal, written, and interpersonal communication skills are required.
  • Prior experience working at a small to mid-sized company with wide ranging related responsibilities is desired.
  • Excellent problem-solving ability.
  • Demonstration of cross-functional understanding related to drug development.
  • Good judge of risks and a keen ability to analyze options and manage outcomes.
  • Leadership and management skills and demonstrated qualities in this area.
  • Excellent negotiation skills and a tactful approach that leads to high value on outcomes achieved.
Physical Demands and Work Environment:
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.

Laboratory Activities (if applicable): Biology and chemical laboratory environment experience needed. Environmental health and safety requirements also apply.

Travel:
You may be required to travel for up to 5% of your time.

The Anticipated Base Salary Range: $173,000-$230,000 
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.

The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience and education. Crinetics Pharmaceuticals is a multi-state employer, and this salary range may not reflect positions that work in other states. Your recruiter can share more about the specific salary range during the hiring process.

Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws

Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.
 

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