Senior Programmer, Pharmacometrics
Position Summary:
The Senior Programmer, Pharmacometrics plays a key role in the Clinical Pharmacology department and is responsible for programming of quantitative analyses in support of internal decision-making and regulatory submissions. This position works closely with the Clinical Pharmacology and pharmacometrics program leads as well as cross-functional team members and external partners to deliver success across all phases of development. Quality control and efficiency are essential. This is a remote (US) based position.
Essential Job Functions and Responsibilities:
These may include but are not limited to:
- Produce real-time analyses to support ongoing study decision-making (interim analyses, Safety Review Committee, etc.)
- Provide exploratory data analyses to support modeling and simulation
- Understand data via graphical and tabular summaries
- Run innovative analyses to help understand potential modeling approaches
- Develop processes for effective figures and data visualizations
- Build out internal capabilities for data visualizations
- Develop process to generate iterative interim figures for rapid interpretation.
- Deliver final high-quality outputs for submissions, presentations, and publications.
- Create dynamic and/or interactive displays to inform and influence stakeholders.
- Create analysis-ready datasets for NCA, population PK, PK/PD, and exposure-response analyses.
- Build analysis datasets from CDISC or interim sources.
- Conduct data cleaning and develop QC processes.
- Deliver specifications and define documentation.
- Bachelor’s or Master’s in a relevant scientific field with 5+ years of experience programming in the pharmaceutical industry. Direct pharmacometrics-related programming experience is a major advantage.
- Substantial experience creating analysis-ready modeling datasets for NONMEM and/or Phoenix NLME.
- Understanding of SDTM and ADaM datasets including ADNCA and ADPPK
- Experience with validation of R, SAS, or other software is desired.
- Must possess graphical programming skills.
- Clinical drug development and clinical pharmacology knowledge desired.
- Ability to work cross-functionally with data managers, programmers, statisticians, and external partners.
- Strong written, presentation and verbal communication skills.
- Expertise in R programming required, SAS programming skills desired. Windows, MS Office (Outlook, Word, Excel, PowerPoint), GraphPad Prism.
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. The noise level in the work environment is typically low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Travel:
You may be required to travel for up to 5% of your time.
In addition to your base pay, our total rewards program consists of a discretionary annual target bonus, stock options, ESPP, and 401k match. We also provide top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance, 20 days of PTO, 10 paid holidays, and a winter company shutdown.
Equal Opportunity Employer:
Crinetics is proud to be an Equal Opportunity Employer. We provide equal employment opportunities to all employees and employment applicants without regard to unlawful considerations of sex, sexual orientation, gender (including gender identity and/or expression), pregnancy, race, color, creed, national or ethnic origin, citizenship status, religion or similar philosophical beliefs, disability, marital and civil union status, age, genetic information, veteran status or any personal attribute or characteristic that is protected by applicable local, state or federal laws.
Vaccination requirement:
Following extensive monitoring, research, consideration of business implications, and advice from internal and external experts, Crinetics requires that all employees and contractors be fully vaccinated and have received the COVID-19 vaccines as a condition of employment. “Full vaccination” is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.