We Are Crinetics


Crinetics is a pharmaceutical company founded in endocrinology research. Our intense focus is on developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. For us, it’s all about these underserved patients, who are eager to find therapies that provide effective disease control and bring more simplicity to their lives. To better achieve these goals, we also partner with endocrinologists and other healthcare practitioners to ensure we’re solving real problems for them.

Discovery Pre-Clinical Phase 1 Phase 2 Phase 3
Paltusotine (SST2 Agonist)
Acromegaly (PATHFNDR-1)
Acromegaly (PATHFNDR-2)
Carcinoid Syndrome
Atumelnant (Oral ACTH Antagonist)
Congenital Adrenal Hyperplasia (CAH)
ACTH-dependent Cushing's syndrome
PTH Antagonist, Hyperparathyroidism
SST3 Agonist, Polycystic Kidney Disease
TSH Antagonist, Graves' Disease, TED
Oral GLP-1 nonpeptide, Diabetes, Obesity
Oral GIP nonpeptide, Diabetes, Obesity
SST5 Agonist, Hyperinsulinism
Radionetics, Targeted Radiotherapy | Multiple Solid-Tumor Oncology Company
Discovery Pre-Clinical Phase 1 Phase 2 Phase 3
Paltusotine (SST2 Agonist)
Acromegaly (PATHFNDR-1)
Acromegaly (PATHFNDR-2)
Carcinoid Syndrome
Atumelnant (Oral ACTH Antagonist)
Congenital Adrenal Hyperplasia (CAH)
ACTH dependent Cushing's syndrome
PTH Antagonist, Hyperparathyroidism
Undisclosed, Polycystic Kidney
TSH Antagonist, Graves' Disease, TED
Undisclosed (Multiple), Diabetes, Obesity
SST5 Agonist, Hyperinsulinism
Radionetics, Targeted Radiotherapy | Multiple Solid-Tumor Oncology Company

Paltusotine


Topline results from Paltusotine Phase 3 PATHFNDR-1 Study
A randomized, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Paltusotine in Subject with Acromegaly Treated with Long-acting Somatostatin Receptor Ligands

Topline Results

CRN04894


CRN04894: An Oral, Nonpeptide ACTH (MC2) Receptor Antagonist Decreased Basal and Stimulated Cortisol Secretion in Healthy Volunteers
Peter J. Trainer, MD1; Christine T. Ferrara-Cook, MD, PhD1; Alejandro Ayala, MD1; Rosa Luo, MS1; Stephanie Miller, BA1; Yang Wang, MSPH1; Martha Hernandez-Illas, MD2; R. Scott Struthers, PhD1; Stephen F. Betz, PhD1; Alan Krasner, MD1
1Crinetics Pharmaceuticals, Inc., San Diego, CA, USA; 2QPS Miami, Miami, FL, USA

Learn more about CRN04894

CARCINOID SYNDROME


Investigational Once-Daily Oral Study Drug for Patients with Carcinoid Syndrome associated with Neuroendocrine Tumors (NETs)
Study centers are enrolling participants for a Phase 2 clinical study, evaluating the safety and potential effects of paltusotine, an investigational once-daily oral drug for patients with carcinoid syndrome associated with neuroendocrine tumors.

LEARN MORE

Contact Us


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We Are Here For the Patients


To us, patients are more than the symptoms they have or the treatments they’re on. You are partners in this work. Real people with friends and families…ideas and insights…hobbies and hopes. Most of all, you have important contributions to make as we pursue solutions that will impact your life. That’s why we pledge to bring five key qualities to every patient relationship:

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Compassion

We will always listen with
our ears and our hearts.

Empathy

Your struggles are not lost on us
and we know how real they are.

Dedication

We embrace the perseverance
that true progress requires.

Focused Intensity

It’s the only way to do this work.

Commitment

This work is important and we give it our all.

To learn more about the relationships we build with patients, send us a message.

Watch Patients Talk About Acromegaly

Compassion

We will always listen with
our ears and our hearts.

Empathy

Your struggles are not lost on us
and we know how real they are.

Dedication

We embrace the perseverance
that true progress requires.

Focused Intensity

It’s the only way to do this work.

Commitment

This work is important and we give it our all.

To learn more about the relationships we build with patients, send us a message.

Watch Patients Talk About Acromegaly